The identities, concentrations and fluxes of these compounds represent the product of interactions that extend from gene sequence to include gene expression, protein expression and the total cellular environment, an "environment" that, in the clinical setting, includes drug exposure. Metabolomics provides a powerful new approach to evaluate global biochemical changes in AD. bring together inpatient, outpatient and emergency behavioral health services as part of a 112,000-square-foot centralized behavioral health center, consolidating services from Duke University and Duke Regional hospitals. Metabolic data are also being integrated with data from imaging studies and other omics data. We host and train MD, PhD, and RN trainees in all phases of academic development to include undergraduate, graduate, practicum, internship, and post-doctoral training experiences. BMRC investigators' research programs cover the entire spectrum of behavioral medicine, ranging from studies of basic mechanisms whereby psychosocial and behavioral factors affect the development and course of medical disorders using techniques of molecular biology and genetics in both animal and human models to the development and evaluation of innovative behavioral treatment and prevention interventions for a broad range of medical disorders, including cardiovascular diseases, pain syndromes, diabetes and gastrointestinal disorders. plasma or urine) that would offer simplicity and cost effectiveness for use in a wide range of settings. We're currently engaged in a number of clinical trials aimed at helping individuals achieve behavioral changes in order to improve their health and functioning in areas such as cardiovascular disease, chronic pain, obesity and weight management and smoking cessation. The overall objective of this study is to use ecological momentary assessment, a real-time, naturalistic data collection method, to prospectively study the impact of reduced frequency of cannabis use on functional outcomes (e.g., mental health symptoms, health-related quality of life) among heavy cannabis users. Pharmacometabolomics could contribute significantly to our attempts to truly individualize drug therapy. The purpose of this study is to determine whether a mobile technology program may help with chronic pain. Tuesday, April 14, 2020 ... Dr. Amy Corneli is an Associate Professor in the Departments of Population Health Sciences and Medicine, and a faculty member of the Duke Clinical Research Institute. Most of our work has focused on two populations for whom this issue is life-threatening: individuals with anorexia nervosa and individuals with type 1 diabetes who withhold insulin to control weight. Pain Management Using Mobile Technology in Veterans with PTSD and TBI The Duke Family Medicine Center is a clinic in Durham offering comprehensive family medicine services for every member of the family, including annual physicals, sports physicals, ongoing care for chronic conditions such as allergies, asthma, and diabetes, and lab services, all in one convenient location. Even before being diagnosed, these babies’ health care utilization patterns are distinctive Children who are later diagnosed with autism and/or attention deficit hyperactivity disorder visit doctors and hospitals more often in their first year of life than non-affected children, suggesting a... ensure the best possible experience and outcomes, Children with Autism, ADHD Have More Doctor and Hospital Visits during Infancy, Duke Psychiatry Professor Blogs about Nature & Resilience in Justice-Involved Communities, Digital Medicine Can Diagnose and Treat What Ails You, Two Duke Psychiatry Faculty Receive Seed Grants to Improve Early Childhood Outcomes, Neurology Grand Rounds - Kafui Dzirasa, MD, PhD (Neurobiology), Visual Attention in ASD: Explorations Across Development, Collision of the Opioid Crisis and the COVID-19 Pandemic: Update and Challenges. This treatment development project is designed to refine a combined treatment for smoking cessation and alcohol use disorder. If you would like to be considered for participation in a future study, please consider joining the Duke Behavioral Health and Technology Data Repository. and develop the next generation of leaders in psychiatry and psychology. This multi-institutional interdisciplinary research consortium involves centers of excellence in metabolomics and metabolomic bioinformatics, together with centers for molecular pharmacologic and pharmacogenomic science that will move beyond focused scientific collaboration to create an environment in which a cooperative, iterative process of hypothesis generation and testing will be applied to achieve the union of metabolomic and pharmacologic science to create pharmacometabolomics. Such studies could also help derive peripheral biomarkers (e.g. Metabolomic signatures can be determined for patients who do and do not respond to drug therapy or patients who do develop or do not develop metabolic side effects. Therefore, they can serve as the basis for the generation and testing of mechanistic hypotheses that address the underlying basis for individual variation in drug response, making it possible to move toward a goal of truly “personalized” or “individualized” drug therapy. Studies include the exploration of genetic, medical, and psychosocial factors associated with the conceptualization, evaluation and treatment of chronic pains in patients with Fibromyalgia and dementias as well as diverse populations that are aging healthily with and without chronic pains. ©2020 Duke University and Duke University Health System, All Rights Reserved. My professional interests include primary care psychiatry, medical education, and integrated care. R21-DA045113 (PIs: Kimbrel/Beckham, Multiple PIs), Using ‘Big Data’ and precision medicine to assess and manage suicide risk in U.S. veterans Led by Rima Kaddurah-Daouk, PhD, the Center for Pharmacometabolomics at Duke is the coordinating center for Pharmacometabolomics Research Network, which includes more than fifteen academic centers. The lack of validated “mega” metabolic platforms has limited the ability to simultaneously study the dozens of different biochemical pathways that may be affected in AD both in relation to each other as well as in relation to other biomarkers and progression. Faculty and staff provide a variety of assessment and treatment services, including psychiatric consultation, medication therapies, and individual, family and group psychotherapy. Duke experts offer a wide range of cognitive behavioral therapies (CBT) to help adults identify and change thinking and behaviors that cause mental health problems. Why choose Duke MedPsych? Optimizing delivery of a behavioral cancer pain intervention. Our team of child psychiatrists, psychologists, social workers, and professional counselors is committed to providing personalized mental health care to your child in … The proposed research is relevant to public health because the findings will indicate whether autonomic nervous system dysfunction, inflammation, and vascular endothelial dysfunction are the direct result of PTSD symptoms or an indirect effect secondary to behaviors related to trauma exposure. . Patient Stress Questionnaire Duke Psychiatry Professor Blogs about Nature & Resilience in Justice-Involved Communities November 13, 2020 Digital Medicine Can Diagnose and Treat What Ails You Although the exact etio-pathobiology of schizophrenia remains elusive, fundamental abnormalities in phospholipids (which play a critical role in membrane structure/ function and neurotransmission) as well as key neurotransmitter pathways (dopamine, serotonin, glutamate) are evident in schizophrenia. This seed money has played an important role in BMRC investigators' success in obtaining over $100M in peer reviewed grant support from the NIH. Its goal is to integrate the rapidly evolving science of metabolomics with molecular pharmacology and pharmacogenomics to move toward the creation of a new discipline: “pharmacometabolomics.”. Advancing behavioral health through exceptional education, ground-breaking research and superior care. Pharmacometabolomics is the use of the techniques of metabolomics to define metabolomic signals that will provide insight into mechanisms of drug action or mechanisms responsible for individual variation in drug response phenotypes. Additionally, we have mapped, in greater detail, perturbations in neurotransmitter and purine pathways (Yao et. With the ultimate goal of developing, implementing and evaluating psychological and lifestyle interventions for primary and secondary prevention of cardiovascular diseases, the laboratory examines mechanisms underlying the development of cardiovascular disease and seeks to better understand the impact of psychosocial factors on health and illness. behavioral medicine and neurosciences, child/family mental health … The Cancer Symptom Management & Support program focuses on conducting clinical research and providing behavioral medicine services to address the psychological, social, behavioral and symptom management needs of cancer patients and their families. Outside of medicine I enjoy movies, traveling, and college sports. 2009 & Patkar et al. The facility is accredited by the American Academy of Sleep Medicine, as are all of our Duke doctors. Duke Health offers a range of evidence-based, patient-centered outpatient clinical services to meet the behavioral health care needs of patients and their families. Our faculty are involved in developing an array of psychosocial interventions to help patients and their family members cope with these challenges. Clinical Associate in the Department of Psychiatry and Behavioral Sciences ... Duke Health School of Medicine Duke University . The department’s 230 active faculty members are organized into three divisions:. The goals of this project include: (1) Quantifying the prospective impact of NSSI on key functional outcomes, including treatment utilization, functional impairment, and risk for suicidal behavior, and (2) Identifying factors that underlie and maintain NSSI in Veterans with PTSD. Participants use iPod touch apps and programs that address and aim to improve different facets of cognitive functioning, and family members are trained as "mentors" to reinforce use of the applications in everyday living environments. This merge has the potential to accelerate advances in our understanding of mechanisms of drug action and individual variations in drug response. The Effect of Reducing Posttraumatic Stress Disorder Symptoms on Cardiovascular Risk provide a 42-bed inpatient behavioral health unit that will consist of … Physicians & Surgeons, Public Health Physicians & Surgeons, Family Medicine & General Practice Physicians & Surgeons. Among the first behavioral medicine programs in the country, Duke draws together experts from clinical psychology, public health, nutrition and medicine. Postdoctoral fellows, cardiology fellows, residents and medical students have the opportunity to participate in this work. These contributions will contribute to the process of personalizing treatment where ultimately the right drug is selected for each. The Duke University School of Medicine comprises 24 clinical and basic science departments consisting of more than 2,500 faculty, 500 medical and 800 health professions students, more than 1000 residents and fellows, and nearly 600 PhD students. VA I01CX001729 (Beckham, PI). Behavioral medicine is an interdisciplinary field focused on the integration of behavioral, psychosocial and biomedical science in an effort to understand, prevent and treat disease. The program is well-established and stable, with strong support and respect from both the Department of Medicine and Department of Psychiatry and Behavioral Sciences. Disgust and fear conditioning in anorexia nervosa, ACT intervention for type 2 diabetes delivered in primary care, Duke Behavioral Health and Technology Data Repository, Child & Family Mental Health & Developmental Neuroscience. Training, focused on behavioral medicine in the oncology setting, is provided for clinical psychology trainees completing postdoctoral training, doctoral internship and practicum rotations as part of doctoral training. Aside from direct patient care, I also work within the Duke Family Medicine Residency Program developing behavioral health curriculum and training residents. 2020 Acceptance and Commitment Therapy (ACT) in Context Research is affiliated with the ACT at Duke program. The Department of Psychiatry & Behavioral Sciences is led by Moira A. Rynn, MD, and a leadership team comprising four vice chairs as well as division directors and education program directors, who assist with the oversight and management of the department's 350+ clinical and research faculty, 70+ residents, fellows and interns, and 300+ staff members. Tag: Behavioral Medicine. Posted 3/9/2018. The Behavioral Medicine Program at Duke University Medical Center is seeking a full-time clinical research assistant beginning on or around June 1, 2017 to assist with an NIH-funded clinical trial examining the effect of aerobic exercise on anxiety symptoms among adults with heart disease. VA Merit Review (Kimbrel, PI), Mobile Contingency Management for Concurrent Abstinence from Alcohol and Smoking This research study involves Veterans using an iPod Touch® and NeuroSky® MindWave headset to practice neurofeedback, which is a form of biofeedback that allows people to train their brains to be in a calmer, more relaxed state. The BSRC also provides training and certification of These include, but are not limited to, psychosocial and medical factors that influence the manifestation of pain in diverse populations of patients with Sickle Cell Disease, diabetes, and chronic regional pain syndromes (CRPS). It uses evidence-based, non-medication approaches to address behavioral, psychological, and physiological factors that interfere with sleep. Both Departments have top categorical residency programs and are national leaders in … Sara Battles, MEd: Clinical Research Coordinator for the Duke Behavioral Health Technology Lab with a Master’s in Education for Counseling. Among the first behavioral medicine programs in the country, Duke draws together experts from clinical psychology, public health, nutrition and medicine. A range of modalities for delivering interventions are being evaluated, including in person, telephone and mobile health technology-based strategies. Duke University Hospital is proud of our team and the exceptional care they provide. (PI Shelby; American Cancer Society), Optimizing delivery of a behavioral cancer pain intervention using a SMART (PI Somers; NIH), In Person and Mobile Health Coping Skills Training for Improving Symptom Management and Daily Steps in Hematopoietic Stem Cell Transplant Patients. Our faculty develop innovative interventions aimed at improving health and functioning in a variety of patient populations that are tested in clinical trials. Research in our laboratory focuses on a range of clinical interests represented by our diverse senior and junior faculty as well as trainees. NIH R34AA023877 (PIs: Dedert and Calhoun), A personalized mHealth approach to smoking cessation for Veterans living with HIV. Our work also extends to other chronic illnesses in which eating, weight and physical activity are central issues in reducing mortality or morbidity risk (e.g., type 2 diabetes), and includes grant-funded research in the area of eating disorders and maladaptive eating and weight control, novel adaptations of ACT and diabetes management; affiliated patient care and training clinic (specializing in ACT); and opportunities for graduate students, interns, residents and fellows to participate in research or related clinical training and services. Medicine, Duke Human Vaccine Institute Medicine, Endocrinology, Metabolism, and Nutrition Medicine, Gastroenterology ... Behavioral Medicine Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology Psychiatry & Behavioral Sciences, Clinical Social Work The overall goal of our research is to develop, implement, and evaluate novel approaches to assess and treat persistent pain, symptoms (e.g., fatigue, nausea) and the physical psychological demands associated with chronic medical illnesses (e.g., cancer, arthritis). The Behavioral Medicine Research Center (BMRC) was founded in 1986, when an anonymous corporate gift established the BMRC endowment, which has grown to its present level in excess of $20M. Our program seeks to understand and treat psychological and psychophysiological contributors and consequences associated with the onset, maintenance, and resolution of chronic pains. Sophisticated metabolomic analytical platforms and informatics tools have been developed that make it possible to begin the process of defining signatures for disease and for response to drugs used to treat disease (see publications list). Behavioral Sleep Medicine (BSM) is an expanding area of psychology that helps patients to achieve better nighttime sleep and daytime functioning. VA 1K2 HX002398 (Wilson, PI), Preventing Suicide through Implementation of Safety Planning for Peer Support Specialists 2007). Journal of Behavioral Medicine Publication Venue For Gain-loss framing and patients' decisions: a linguistic examination of information framing in physician-patient conversations. The goal of this project is to examine the underlying cause of PTSD by evaluating genetic variants, DNA methylation and environmental influences in trauma exposed populations. The Division of Behavioral Medicine and Clinical Psychology at Cincinnati Children's Hospital anticipates hiring for multiple full-time clinical research positions. Schizophrenia is arguably one of the most disabling of all diseases, being relatively common, with onset typically in adolescence and running a lifelong disabling course. Projects within the Pharmacometabolomics Research Network: The Behavioral Medicine Research Center (BMRC) was founded in 1986, when an anonymous corporate gift established the BMRC endowment, which has grown to its present level in excess of $20M. 20.4 miles. firstname.lastname@example.org Periodically, we have new opportunities for people to participate in our studies. Alzheimer’s disease (AD) is the leading cause of dementia, affecting over five million people in the U.S., with more than 10 million aging baby boomers estimated to be at risk in the coming decades. Duke Clinic 40 Duke Cir. Applying scientific methods, we study, evaluate and treat chronic pains in a wide range of disease states including low back, failed back surgery syndromes, fibromyalgia, sickle cell disease, headaches, trauma and injury related pains, neuropathic conditions, phantom limb pains, post-surgical pains, urological and gastric pains. Comprised of leading experts in the fields of genetics, metabolomics, neuroimaging, bioinformatics, and clinical trials, the MDPMC’s mission is to achieve the precision medicine goals of individualizing treatment for mood disorder patients based on an integrated biological understanding of their illnesses and variation in response to treatments. In addition, a listing of Duke behavioral health providers that are considered network providers for Duke employees and their dependents is available here. Through our schizophrenia research, we have used lipidomics analysis and confirmed that there are major changes in phospholipids early in the disease process (Kaddurah-Daouk et al. The Duke PA Program makes no recommendations or guarantees about the positions and employers listed here, and are not responsible for safety, wages, working conditions, or other aspects of employment. Duke CFAR Social and Behavioral Sciences (SBS) Core Confidentiality and Integrity Statement. Approximately five percent of patients end their lives by suicide and overall patients die prematurely (from cardiometabolic deaths not just suicide) some 25 years earlier than the general population. Those phenotypes can vary from life threatening adverse drug reactions to lack of the desired therapeutic efficacy. In Annals of Behavioral Medicine, 54:S141–S141, 2020. Schizophrenia, by any estimate a devastating condition, is characterized by highly distressing positive symptoms (e.g., delusions and hallucinations), negative symptoms (e.g., impaired volition, and emotion), impaired cognition and social functioning. The Pharmacometabolomics Research Network is a collaborating network established with funding from NIGMS. Duke Child and Family Trauma Program faculty serve in national and international leadership positions in the field of child traumatic stress. Read the related publication. Metabolomics has been identified as an important area for technical development under the NIH Roadmap Initiative. 2007). We also treat conversion disorders and somatoform presentations that include pain and neurological symptoms. Responsibilities include patient recruitment, assisting with study assessments, data BMRC financial support of the collaboration between Department of Psychiatry & Behavioral Sciences health psychologists and the Arts & Science Department of Psychology & Neuroscience played an important role in the Clinical Psychology PhD program in the Department of Psychology & Neuroscience being ranked among the top 10 programs in the U.S. At the Duke Behavioral Health & Technology Lab, we look for new ways to improve health and well-being through the use of mobile technology and behavioral health interventions. IK2 CX000525 VA Clinical Science Research and Development (Kimbrel, PI), Genetic and Epigenetic Dissection of PTSD bring together inpatient, outpatient and emergency behavioral health services as part of a 112,000-square-foot centralized behavioral health center, consolidating services from Duke University and Duke Regional hospitals. Duke faculty lead and collaborate with other scientists nationwide in many of the clinical trials that define the evidence base for clinical best practices. Behavioral Sleep Medicine (BSM) is an expanding area of psychology that helps patients to achieve better nighttime sleep and daytime functioning. Faculty and staff provide a variety of assessment and treatment services, including psychiatric consultation, medication therapies, and individual, family and group psychotherapy. The laboratory uses contextual behavioral science to understand and treat human suffering. The objectives of this multi-site, multi-PI project, which is jointly funded by a VA CSRD Merit Award, VACO, and the Department of Energy (DoE) are to: (1) use machine learning and AI to develop personalized, longitudinal risk scores for acute suicidal behavior in Veterans; (2) conduct the largest GWAS of suicidal behavior to date among ~450,000 Veterans; (3) develop tools that will help VA clinicians and administrators identify high-risk Veterans as well as effective interventions and public health approaches to reduce the occurrence of death by suicide and suicidal behavior among Veterans. The Duke Family Medicine Center is a clinic in Durham offering comprehensive family medicine services for every member of the family, including annual physicals, sports physicals, ongoing care for chronic conditions such as allergies, asthma, and diabetes, and lab services, all in one convenient location. Duke Health Profile The Duke Health Profile (Duke) is a 17-item standardized self-report instrument containing six health measures (physical, mental, social, general, perceived health, and self-esteem), and four dysfunction measures (anxiety, depression, pain, and disability). Unrestricted research support for 10+ senior BMRC investigators from various departments and disciplines has enabled them to undertake pilot studies, enhance ongoing studies and support trainees who work on their research projects. Duke Integrative Medicine… Evaluation of an intervention to improve adherence and symptom management for breast cancer patients taking adjuvant endocrine therapies. “ Connecting Caregivers to Support: Lessons Learned From the VA Caregiver Support Program. The Duke Behavioral Medicine Division provides preventive, diagnostic, and therapeutic services to a wide variety of patient populations and presenting problems that are caused or exacerbated by psychosocial and behavioral processes including: The purpose of this project is to identify how genetic and epigenetic factors interact with trauma exposure to predict PTSD and other forms of psychopathology among Iraq/Afghanistan-era veterans. These faculty function as high level researchers, treatment and assessment developers, certified trainers in trauma’s evidence-based treatments (EBTs) for children and families, and with productivity in grants, journal articles, books, and curricula. Click on a faculty member’s name to view their profile, including their grants and publications. Through our addiction research, we have mapped metabolic signatures for exposure to cocaine and opioids (Mannelli et al. Built in 1930 as the original Duke Hospital building, Duke Clinic (sometimes called Duke South) is now home to the School of Medicine and the medical center's outpatient clinics. Megan Lanier, BS: Clinical Research Specialist with the Duke Behavioral Health and Technology Lab, Alexandra Thompson, BS: Clinical Research Specialist with the Duke Behavioral Health and Technology Lab, Mechanisms of psychosocial interventions for chronic back pain, including cognitive therapy, behavioral therapy and mindfulness, Perisurgical coping skills intervention to enhance the outcomes of knee replacement surgery in osteoarthritis patients, Adherence and symptom management intervention for breast cancer patients taking adjuvant endocrine therapies, Lifestyle interventions, including exercise, coping skills training and stress management, DASH diet and weight reduction, Mobile health (mHealth) applications to promote behavioral change, Tele-health to increase reach of behavioral interventions, Ambulatory monitoring of physiology and behavior, Behavioral interventions to reduce substance misuse (smoking, alcohol, cannabis), Behavioral interventions to increase physical activity, Real-time assessment and intervention strategies, Use of acceptance, mindfulness and values in the treatment of maladaptive eating and weight control, Restriction, binge eating and insulin omission, Virtual reality eating disorder prevention programs, Development of an ambulatory device to train emotional awareness and emotion regulation, Acceptance-based separated family treatment for adolescents with anorexia nervosa, Real-time bio-behavioral precursors to eating disorder symptoms among individuals with type 1 diabetes, mHealth intervention for individuals with type 1 diabetes who restrict insulin to lose weight, Appetite regulation among individuals with type 1 diabetes, Pre-surgical/ procedure psychological screening, Coping skills training/ Relaxation training, Natural language psychological testing and interventions (Spanish), Diagnostic assessments and psychotherapy with multicultural and diverse populations to include natural language Spanish evaluations and treatment.
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